Labelling Basement Membrane Of Skin:

OVERVIEW:

LABEL DISEASES ASSOCIATED WITH BASEMENT MEMBRANE PROTEINS:

MOLECULAR COMPONENTS OF BASEMENT MEMBRANE ZONE:

VIVA QUESTIONS:

Q1: What are Adherens junctions?

A: Adherence Junctions are electron dense, transmembrane structures that engage with actin skeleton.  They can associate with tight junctions and desmosomes.

Q2. What are Gap junctions?

A: Also known as connexins, which directly form connection between the cytoplasm of adjacent keratinocytes and other cells. 

Q3:  What are Hemi-desmosomal proteins?

A: The hemidesmosomes are seen ultrastructurally as electron dense attachment complexes which extend from intracellular compartment of the basal keratinocytes to lamina lucida in the upper portion of dermoepidermal basement membrane. 

Q4: What are the laminins?

A: Laminins are other structures that contribute to the formation of BMZ. The major laminin present within the BMZ is Laminin 332, previously known as Laminin 5

Q5: Major collagen present in Basement membrane?

A: Collagen IV